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Journal of Clinical and Applied Neurosciences                            Volume 1; Issue 1                                   Jan-Jun 2015
ORIGINAL ARTICLE
Brain astrocytomas in South-East Nigeria: a 3-centre experience
Enoch O UCHE1, Jude-Kennedy C EMEJULU3, Emeka OKORIE1,4, Ephraim E ONYIA1,  Izuchukwu ILOABACHIE1, Nkechinyere J UCHE5, Francis NNAKENYI6, Obinna AJUZIEOGU2, Martin NZEGWU6, Martin NNOLI7, Angela MUOBIKE8


AFFILIATIONS
1Neurosurgery Unit
2Department of Anaesthesia
5Dept of Ophthalmology
6Department of Pathology
University of Nigeria
Teaching Hospital
Ituku-Ozalla, Enugu, NIGERIA

3Neurosurgery Unit
Nnamdi Azikiwe University
Teaching Hospital, Nnewi 
Anambra State, NIGERIA

4Nerosurgery Unit
7Department of Anatomic
and Forensic Pathology
Federal Medical Centre
Umuahia, Abia State, NIGERIA

8
Division of Surgery
Annunciation Specialist Hospital, Emene, Enugu
NIGERIA
CORRESPONDING AUTHOR
Dr Enoch O UCHE
Department of Surgery
University of Nigeria
Teaching Hospital
Ituku-Ozalla, Enugu State NIGERIA

Email: enoch.uche@unn.edu.ng <mailto:enoch.uche@unn.edu.ng>
Phone: +234 803 368 6469
DISCLOSURES: NONE
ABSTRACT
Background: Although astrocytomas are the most common primary brain tumours worldwide, they are still poorly reported in our environment.
Methodology: We retrospectively studied adult patients with astrocytic tumours treated over a 5-year period in 3 tertiary hospitals within South-East Nigeria.  Patients’ clinical data as well as radiology and histology reports were analyzed. Follow-up interval was 3months to 4.5 years. Data analysis was performed using SPSS version 16 with evaluation of confidence limits at the 95% level of significance.
Results: A total of 231 patients with computed tomography / magnetic resonance imaging diagnoses of brain tumours were seen, 61 patients had features of brain astrocytoma and were studied, while 46 had histological confirmation. Age range was 16-77 years with a mean of 43.4±1.7 years (95% CI). The mean age for those with low grade tumours was 35.3±0.9years (95%CI) and 49.6±0.4years for high grade tumours (95%CI), and the male:female ratio was 1.5:1. Major complaints were headache and seizures in 70.5% (43 patients) and 58.3% (35 patients), respectively, while duration of symptoms was 2 to 17months, with a mean of 9.6±1.7 (95%CI) months. The tumours in 41 cases were supratentorial, 17 cases were infratentorial, while 3 cases were transtentorial. Of the cases that had operative treatment, 33patients had microsurgical resections, 11 had biopsy only, while 31 had cerebrospinal fluid diversion. Histologically, 13 patients had low grade tumours (WHO grades I and II), while 36 patients had high grade (WHO grades III and IV). Survival rates after 1year and 3years follow-up were 77% and 61% for low grade tumours and 27% and 8.3% for high grade tumours.
Conclusion: There is a need to establish a national brain tumour registry to properly evaluate the profile of brain tumours including astrocytomas.

Keywords
: Brain tumours, computed tomography, histology, magnetic  resonance imaging, survival

Received: 10th February, 2015                                                              Accepted: 25th March, 2015